Determination of Acrylamide in Water, Paperboard and Foodstuff by Isotope Dilution Liquid Chromatography and Tandem Mass Spectrometry
ALS Environmental has developed special prep procedures for water, paperboard and complex food matrices, followed by liquid chromatography tandem mass spectrometry (LC-MS/MS) for the analysis of acrylamide. Using this prep and analytical approach, ALS Environmental is able to achieve method reporting limits (MRL) of 0.1 μg/L in water and 1 μg/kg for acrylamide in paperboard and foodstuff.
Acrylamide is classified by the International Agency for Research on Cancer (IARC) as a potential carcinogen to humans1. The formation of acrylamide in fried, roasted or baked foods has been hypothesized as a product of the Maillard reaction of asparagine and glucose2. Acrylamide has been measured in bread and candy at low μg/Kg (ppb) concentrations, and in coffee, biscuits and potato chips at high μg/Kg (ppb) concentrations3. The USEPA and the EU have set regulatory limits on acrylamide levels in drinking water at 0.5 μg/L and 0.1 μg/L, respectively.4
Acrylamide chemical structure
- Yu Zhang a, Genyi Zhang b, Ying Zhang. Occurrence and analytical methods of acrylamide in heat-treated foods - review and recent developments. Journal of Chromatography A, 1075 (2005) 1–21.
- Jose´ A. Rufia´n-Henares, Francisco J. Morales. Determination of acrylamide in potato chips by a reversed-phase LC–MS method based on a stable isotope dilution assay. Food Chemistry 97 (2006) 555–562.
- Cheong Tae Kim, Eun-Sun Hwang, Hyong Joo Lee. An improved LC-MS/MS method for the quantitation of acrylamide in processed foods. Food Chemistry 101 (2007) 401–409.
- Lucentini L., Ferretti E., Veschetti E., Achene L., Baldassarri L., and Ottaviani. Determination of Low-Level Acrylamide in DrinkingWater by Liquid Chromatography/TandemMass Spectrometry. Journal of AOAC International Vol. 92, No. 1, 2009.
View Arcrylamide CAS 79-06-1 on the Proposition 65 List...