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Archive for April, 2003

Method Development for Addressing Emerging Chemicals of Concern in the U.S.

Friday, April 4th, 2003

A number of relatively new chemical compounds are becoming more significant from a regulatory standpoint. These are commonly called “emerging chemicals” or “emergent chemicals”, which simply refers to the fact that they are coming into view as potential bad actors from a human health and ecological risk standpoint. Some of the chemicals are not particularly new in terms of environmental monitoring (e.g. Hexavalent Chromium, 1,4-Dioxane, etc.), but lower detection limits are required or about to be required. Other compounds are relatively new compared to the routine lists of SOCs and VOCs that have been reported for the past several decades. As discussed in a separate article of this issue of the CAS Connection, Polybrominated Diphenyl Ethers (PBDE) is a class of compounds that have attracted a great deal of attention just within the last year or two. Another subset of compounds that is generally referred to as Personal Care Products (PCP) is also a topic of considerable discussion. Examples of these are antibiotics, estrogens, analgesics, etc. Of the PCPs, some are known to be endocrine disrupters.

Studies are underway in a number of private and government organizations to gain more knowledge regarding the relative propensities for certain compounds to disrupt the endocrine systems of various living organisms, including mammals. CAS is staying abreast of these emerging chemicals and continuously working to bring viable methods on line. In some cases, relatively sophisticated procedures are in place to satisfy new requirements. The table above lists a few of the procedures for analysis of emerging chemicals that CAS is currently performing.

Low Level Analysis of 1,4-Dioxane by EPA Method 8270C SIM with Large Volume Injection

Friday, April 4th, 2003

Low Level Analysis of Dioxane1,4-Dioxane has been used for many years as a stabilizing agent in the production of chlorinated solvents to prevent breakdown during manufacturing processes. It is also present in many household products like soaps, shampoos, baby lotion and cosmetics.

Over the past few years 1,4-Dioxane has garnered increased attention due to it’s presence in groundwater at several California locations and because there is little scientific data available on the longterm effects on human health. An additional concern is that traditional remediation technologies used for sites contaminated with chlorinated solvents are ineffective at removing 1,4-Dioxane.1