Lab Science News - Science, chemistry and environmental news from laboratory experts

PFOA and Related Compounds

April 30th, 2008

PFOAs may adversely affect the liverIn the early 2000s, the EPA began to investigate the synthetic compound Perfluorooctanoic Acid (PFOA or C8) and its salts, primarily Ammonium Perfluorooctanate (APFO) and other fluoropolymers that may metabolize or degrade into PFOA. These compounds are of interest because of their similarity to another compound known as Perfluorooctyl Sulfonate (PFOS). PFOS was designated a persistent organic pollutant and the primary worldwide manufacturer ceased making it in 2001.

There is still controversy over PFOA’s toxicity, though the compound is persistent (doesn’t biodegrade, hydrolyse or photolyse), bioaccumulates in human and animal tissue (binds to proteins in the blood and liver), and biomagnifies up the food chain. In 2007, the Center for Disease Control and Prevention published the results of two studies on the levels of 11 different polyfluorochemicals in humans. In those studies PFOS, PFOA and Perfluorohexane Sulfonic Acid (PFHS) were found in 98% of those tested, confirming widespread exposure to these compounds. Exposure may occur through consumption of contaminated food or water or through the use of products containing these compounds, but not all sources are known or understood.

PFOA is a polymerization aid used in the manufacturing of fluoropolymers. The carbon fluorine part of the molecule is water resistant, which makes them valuable in producing fluoropolymer products that can repel water, grease and oil. These compounds are used in making non-stick surfaces for cookware, stain resistant clothing, carpets and other fabrics and in fire fighting foams. It is because of its unique polar anionic chemical properties that traditional models used to predict chemical behavior of non-polar organic chemicals, like PCBs or dioxins, in wildlife and humans, cannot be extrapolated from standard experimental data on mice and rats. In rodents PFOA has been shown to be carcinogen and immunotoxic, but whether this can be translated into information about its effect on humans is not clear. Studies continue. It should be noted, in February 2006, the EPA’s Science Advisory Board voted to approve a recommendation that PFOA should be considered a likely carcinogen.

The principal fluoropolymer producers committed to a minimum 50-percent reduction in total global emissions by 2006 (using 2000 as the baseline year), 95% reduction in emissions and product content by 2010 and elimination of its use altogether by 2015. However, because of the persistence of these compounds in the environment and the bioaccumulation and biomagnification in the food chain these compounds will continue to be in the environment long after manufacturing ceases.

Perfluorinated compounds are large molecules and are not amenable to common analytical techniques such as Gas Chromatography/Mass Spectroscopy (GC/MS).


  1. United States Environmental Protection Agency, Basic Information on PFOA. March 31, 2008.
  2. United States Centers for Disease Control and Prevention, National Report on Human Exposure to Environmental Chemicals, Spotlight on Polyflurorchemicals, August 2007.
  3. US EPA Mid Continent Ecology Division, Research Project Summary, Toxicity and Accumulation of PFOS in Frogs
    and Small Fish, January 2008.

  4. Perfluorooctanioc (PFOA), Fluorinated Telomers; Request for Comment, Solicitation of Interested Parties for Enforceable Consent Agreement Development, and Notice of Public Meeting, Federal Register, April 16, 2003, Volume 68, Number 73, Pages 18626-18633.
  5. US EPA Newsroom, EPA Seeking PFOA Reductions, Release date 1/25/2006.
  6. US EPA Newsroom, EPA Settles PFOA Case Against Dupont for Largest Environmental Administrative
    Penalty in Agency History, Release date 12/14/2005.


Related Posts Plugin for WordPress, Blogger...

Tags: , , , , , , , , , , ,

5 Responses to “PFOA and Related Compounds”

  1. victor hahn Says:

    Do you have the capability of analyzing PFOA and PFOS in wastewater?

  2. admin Says:

    Yes, we run PFOA and PFOS. Let us know if you have any questions and how we may assist you.

  3. nora casey Says:

    Is there any accessible ways of testing for PFOA in drinking water?

  4. admin Says:

    As of September 27th, 2010, there is no required regulatory test method for PFOAs in drinking water proscribed by the EPA’s Office of Safe Drinking Water. However, we understand that they are working on a method and it will use the same instrumentation that we currently use to test for the PFOA compounds – an LC/MS/MS (liquid chromography, dual mass spectrometer also know as a triple quad). We have used this instrument and our in-house, performance-based method to test for PFOAs in drinking water samples.

    If you would like more information about this method please contact Chris Leaf at 360-577-7222.

  5. Don Says:


    My family was exposed to teflon fumes and associated particles via a drip/cookie pan in the bottom our oven for about 8 months. I discovered the pan was discoloured when I removed the last piece of foil that was on it.. My wife and I are both having some bowel issues after the fact. I am currently trying to locate a lab that can test for these contaminant released by teflon products. No one I have called, including the Canadian government, can tell me where I can get blood tested, and what exactly I should look for? Could you please help me with this? I thank you in advance for any assistance you may offer.


Add Your Comments, Questions, or Feedback: