Lab Science News - Science, chemistry and environmental news from laboratory experts

Posts Tagged ‘HPLC’

USP 467 for Residual Solvents: Manufacturers Face Challenges with Pharmaceutical Impurities

Wednesday, October 14th, 2009

Residual SolventsPharmaceutical manufacturers may face various challenges when attempting to meet the United States Pharmacopeia (USP) requirements for residual solvents (volatile organic chemicals).

Residual solvents in pharmaceuticals are trace level impurities of volatile organic compounds in final products or excipients. In general, residual solvents originate from manufacturing processes related to the preparation of drug products. They can also form during product packaging and storage.

Read more about USP 467…

Emerging Chemicals of Concern for the Environment by SPE coupled with HPLC and HPLC/MS/MS Detection

Sunday, July 4th, 2004

Emerging Chemicals of Concern for the Environment by SPE coupled with HPLC and HPLC/MS/MS DetectionThe USGS has identified 95 organic wastewater contaminants (OWC’s) of concern (Kolpin et al. 2002). In this study, 80 percent of streams sampled contained measurable levels of OWC’s. This list consists of many new classes of organic compounds not amenable to the more common EPA GC and GC/MS standard analytical methods. These new classes of compounds include veterinary and human antibiotics, human drugs, industrial and household hazardous wastewater and multiple classes of hormones, which are generally larger and less volatile than analytes found on current EPA method lists. Reversed phase HPLC analysis with a polar mobile phase is particularly suitable to analyzing large molecules that exhibit low volatility. HPLC methods have been developed by Columbia Analytical Services in Kelso for the analysis of a wide range of these compounds utilizing UV and fluorescence detectors. Methods already developed include a number of estrogens and caffeine and its metabolites.