Columbia Analytical Services

Japan National Institute of Environmental Studies (NIES) Signs Licensing Agreement with CAS for Dioxin Screening Cell Line

CAS has granted a license to the NIES, a Japanese non-profit research organization closely affiliated with the Japan Ministry of Environment, to conduct basic studies on Persistent Organic Pollutants (POPs) and quick screening analytical methods for the measurement of dioxins and dioxin-like compounds, using CAS’ exclusive P450 Human Reporter Gene System (HRGS) cell line.

NIES’ Research Center for Material Cycles and Waste Management will conduct this research as part of an effort to find alternative, cheaper and quicker methods to the only approved method in Japan for the measurement of dioxins – high resolution GC/MS.

Dioxin and related compounds are a serious issue in Japan because of the number of incinerators in use for waste management, and the close proximity of the Japanese populace to industry and pollution sources.

CAS has the exclusive, worldwide rights to the bioengineered human liver cell line. Over the years, CAS has developed a method, approved by the United States EPA as Method 4425, to screen for dioxin and dioxin-like compounds at sub parts per billion levels in soil, water and tissue.

CAS has a commercial partner in Japan, Nihon Environmental Services Company, that is currently performing services for customers in Japan using this cell line. They will cooperate with NIES in their studies.

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4 Responses to “Japan National Institute of Environmental Studies (NIES) Signs Licensing Agreement with CAS for Dioxin Screening Cell Line”

  1. Teacher Andy Says:


    I would like to ask whether your lab is capable of determining K-40 in food?

    Best regards,
    Teacher Andy

  2. Dee O'Neill, Columbia Analytical Says:

    Testing for K-40, the radioactive isotope of potassium, would have to be
    done by a laboratory that tests for radioactive analytes. We do not
    perform analyses of radioactive analytes at the present time. There are
    a number of labs in many countries including the Philippines that do
    that type of testing. I would suggest that you contact the Philippines
    Environmental Management Bureau for a list of properly certified
    companies to perform this type of testing.

  3. David Cheong Says:


    Can your lab test for Dioxine in Feed Additives?



  4. Dee O'Neill, Columbia Analytical Services Says:

    Yes, we do test feed and feed additives for dioxin. These tests are better performed in a fixed lab, not via the P450 cell line. Please let us know if you would like our dioxin lab to prepare a quote for you. All We would need to know is how many samples and whether you need all 17 isomers on the WHO list or just TCDD and TCDF.

    Dee O’Neill

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